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SCID
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life
Synonyms:
SCID; severe combined immunodeficiency; severe combined immunodeficiency disease
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("SCID" is a kind of...):
immunodeficiency (immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced)
monogenic disease; monogenic disorder (an inherited disease controlled by a single pair of genes)
Hyponyms (each of the following is a kind of "SCID"):
ADA-SCID (SCID resulting from mutation of a gene that codes for adenosine deaminase)
X-linked SCID; X-SCID (SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor)
Context examples:
Development of a newborn screening test has made it possible to detect SCID before symptoms appear.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
An autosomal recessive deficiency of the purine salvage enzyme adenosine deaminase which results in Severe Combined Immunodeficiency Disease (SCID).
(Adenosine Deaminase Deficiency, NCI Thesaurus)
The Phase 1/2 trial reported today enrolled eight infants aged 2 to 14 months who were newly diagnosed with X-SCID and lacked a genetically matched sibling donor.
(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)
If untreated, SCID is fatal, usually within the first year of life.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
Infants with X-SCID typically are treated with transplants of blood-forming stem cells, ideally from a genetically matched sibling.
(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)
Approximately three-quarters of SCID infants who received transplants survived for at least five years.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
To restore immune function to those with X-SCID, scientists developed an experimental gene therapy that involves inserting a normal copy of the IL2RG gene into the patient’s own blood-forming stem cells.
(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)
Infants with SCID appear healthy at birth but are highly susceptible to infections.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
Eight infants with the disorder, called X-linked severe combined immunodeficiency (X-SCID), received an experimental gene therapy co-developed by National Institutes of Health scientists.
(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)
SCID is caused by defects in genes involved in the development and function of infection-fighting T and B cells.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
