Health / Medical Topics

    SFRP1 wt Allele

    Human SFRP1 wild-type allele is located in the vicinity of 8p11.21 and is approximately 48 kb in length. This allele, which encodes secreted frizzled-related protein 1, plays a role in the modulation of Wnt signaling. Methylation of the gene is associated with decreased expression and may be a factor in both colon and breast cancer. (NCI Thesaurus)




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