| Health / Medical Topics |
Small Inducible Cytokine C1
Expressed in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary by human XCL1 Gene (Intercrine Gamma Family), 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1 is similar to CCL8 and CCL3, but lacks the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI Thesaurus)
YOU MAY ALSO LIKE
