Small Inducible Cytokine B10

Definition 1

A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor. IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions. The IP10 gene is a RAS signaling target. (from OMIM 147310 and NCI) (NCI Thesaurus)

Definition 2

Encoded by Interferon Gamma-induced human CXCL10 Gene (Intercrine Alpha/Chemokine CXC Family), secreted 98-aa 11-kD (precursor) Small Inducible Cytokine B10 is a chemotactic chemokine ligand for receptor CXCR3 that causes stimulation of monocyte, natural killer cell, and T-cell migration, and modulation of adhesion molecule expression. (NCI Thesaurus)

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