Small Inducible Cytokine A8

Definition 1

Chemokines, a family of small cytokines, attract leukocytes and possess various immunomodulating functions. CC chemokines influence mononuclear cell types. Human Macrophage Chemoattractant Protein-2 is a chemotactic factor for monocytes, lymphocytes, basophils and eosinophils. This monomer or homodimer can bind heparin. Its expression is induced by interferon gamma, mitogens, and IL-1. (from OMIM 602283, Swiss-Prot P80075, and NCI) (NCI Thesaurus)

Definition 2

This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. (NCI Thesaurus/LocusLink)

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