Small Inducible Cytokine A5

Definition 1

A member of the interleukin-8 superfamily of cytokines, RANTES is released from platelets and activated T-cells, and is a selective chemoattractant for eosinophils, monocytes, and memory T-lymphocytes. RANTES expression is increased more than ten-fold in peripheral lymphocytes following mitogenic or antigenic stimulation. RANTES is one of the natural ligands for the chemokine receptor CCR5. Chemokines RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells. (from OMIM 187011 and NCI) (NCI Thesaurus)

Definition 2

This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. (NCI Thesaurus/LocusLink)

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