| Health / Medical Topics |
Somatostatin Receptor 5
Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase. The Somatostatin Receptor 5 and D2R GPCRs interact to create a novel receptor with enhanced activity; either ligand promotes heterodimerization. SSTR5 increases DNA synthesis, whereas SSTR2 inhibits DNA synthesis and cell proliferation. SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors. SSTR5 is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. (from OMIM 182455, SWISS-PROT P35346, and NCI) (NCI Thesaurus)
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