Library / English Dictionary

SSRI

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

An antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain

Synonyms:

selective-serotonin reuptake inhibitor; SSRI

Classified under:

Nouns denoting man-made objects

Hypernyms ("SSRI" is a kind of...):

antidepressant; antidepressant drug (any of a class of drugs used to treat depression; often have undesirable side effects)

Hyponyms (each of the following is a kind of "SSRI"):

fluoxetine; fluoxetine hydrocholoride; Prozac; Sarafem (a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain)

paroxetime; Paxil (a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Paxil))

sertraline; Zoloft (a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft))

Credits

 Context examples: 

As a selective serotonin reuptake inhibitor (SSRI), citalopram selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS).

(Citalopram Hydrobromide, NCI Thesaurus)

The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties.

(Escitalopram, NCI Thesaurus)

A research team set out to solve the structure of the human serotonin transporter and determine how selective serotonin reuptake inhibitors (SSRIs) interact with it.

(Serotonin transporter structure revealed, NIH)

Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding.

(Escitalopram, NCI Thesaurus)

The SSRIs also fit in a second site on the protein, called an “allosteric” site, which affects how quickly molecules can get out of the central pocket.

(Serotonin transporter structure revealed, NIH)