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Sulindac
Pronunciation
Definition 1
A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer. (NCI Dictionary)
Definition 2
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI Thesaurus)
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