Library / English Dictionary

TAMOXIFEN

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

An antagonist for estrogen that is used in the treatment of breast cancer

Synonyms:

estrogen antagonist; tamoxifen

Classified under:

Nouns denoting man-made objects

Hypernyms ("tamoxifen" is a kind of...):

antagonist (a drug that neutralizes or counteracts the effects of another drug)

Credits

 Context examples: 

A form of the drug tamoxifen that is made by the body after taking tamoxifen.

(Afimoxifene, NCI Dictionary)

A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM).

(Droloxifene, NCI Thesaurus)

Of the newly-discovered genetic variants, a third predispose women towards developing hormone-responsive breast cancer, the type of disease found in four out of five breast cancer patients, which respond to hormonal treatments such as tamoxifen. 15% of the genetic variants predispose women to the rarer type, estrogen-receptor-negative breast cancer.

(Detailed genetic study provides most comprehensive map of risk to date of breast cancer risk, University of Cambridge)

In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene exhibits greater bioavailability and higher anti-estrogenic potency in the breast than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene.

(Arzoxifene hydrochloride, NCI Thesaurus)

Consistently with G1 arrest, icaritin increases protein expressions of pRb, p27(Kip1) and p16(Ink4a), while decreasing phosphorylated pRb, Cyclin D1 and CDK4. 40% of ER-negative breast cancer tumors express high levels of ERa36, and this subset of patients is less likely to benefit from tamoxifen treatment compared with those with ERa66-positive/ERa36-negative tumors.

(ERa36 Modulator Icaritin, NCI Thesaurus)

Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding.

(Fulvestrant, NCI Thesaurus)

A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity.

(N-Desmethyltamoxifen, NCI Thesaurus)

A tamoxifen metabolite with both estrogenic and anti-estrogenic effects.

(Afimoxifene, NCI Thesaurus)

Part of the National Surgical Adjuvant Breast and Bowel Project, the Breast Cancer Prevention Trial (BCPT) was a clinical trial designed to see whether taking the drug tamoxifen would prevent breast cancer in women who are at an increased risk of developing the disease.

(Breast Cancer Prevention Trial, NCI Thesaurus)

N-desmethyltamoxifen is further hydroxylated, mainly by CYP2D6, to endoxifen, the major clinically active metabolite of tamoxifen.

(N-Desmethyltamoxifen, NCI Thesaurus)