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Tetrahydrouridine
Pronunciation
Definition 1
A substance being studied in the treatment of some types of cancer. It may help make cancer cells easier to kill with radiation therapy. Tetrahydrouridine is a type of radiosensitizing agent, a type of multidrug resistance modulator, and a type of cytidine deaminase inhibitor. Also called THU. (NCI Dictionary)
Definition 2
A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine). (NCI Thesaurus)
Definition 3
A substance that makes tumor cells more sensitive to radiation therapy and is being studied in the treatment of cancer. It belongs to the families of drugs called cytidine deaminase inhibitors, multidrug resistance modulators, and radiosensitizers. (NCI Dictionary)
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