Toll-Like Receptor 5

Highly expressed in ovary and myelomonocytic cells by human TLR5 Gene (TLR Family), 858-aa 98-kDa (precursor) type I membrane protein Toll-Like Receptor 5 contains a TIR domain and 15 LRR repeats. Mediating detection of bacterial flagellin (a virulence factor), TLR5 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Likely bound to MyD88 via the TIR domains, TLR5 acts via MyD88 and TRAF6, leading to NF-Kappa-B activation, TNF-alpha production, and the inflammatory response. (NCI Thesaurus)

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