| Health / Medical Topics |
Toll-Like Receptor 8
Expressed in lung, brain, heart, liver, placenta, monocytes, peripheral leukocytes, and CD11c+ immature dendritic cells by human TLR8 Gene (TLR Family), 1041-aa 120-kDa (precursor) type I membrane protein Toll-Like Receptor 8 contains a TIR domain and 24 LRR repeats. TLR8 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR8 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI Thesaurus)
YOU MAY ALSO LIKE
Expressed in lung, placenta, spleen, brain, stomach, small intestine, and pre-dendritic cells by human TLR7 Gene (TLR Family), 104-aa 121-kDa (precursor) type…
Expressed in monocytes, CD11c+ immature dendritic cells, and dermal endothelial cells by human TLR6 Gene (TLR Family), 796-aa 92-kDa (precursor) type I…
Highly expressed in ovary and myelomonocytic cells by human TLR5 Gene (TLR Family), 858-aa 98-kDa (precursor) type I membrane protein Toll-Like Receptor…
Expressed most in placenta, spleen, and myelomonocytic leukocytes by human TLR4 Gene (TLR Family), isoforms A-D of 96-kDa (precursor) type I membrane…
Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes by human TLR3 Gene (TLR Family), 904-aa 104-kDa (precursor) type I membrane…
Highly expressed in monocytes, bone marrow, lymph node, and spleen by human TLR2 Gene (TLR Family), 784-aa 90-kDa (precursor) type I transmembrane…
