Transporter 2, ATP-Binding Cassette, Sub-Family B

Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP2 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. (From LocusLink 6891, PMID 11773612 and NCI) (NCI Thesaurus)

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