| Health / Medical Topics |
Apoptosis-Stimulating of p53 Protein 2
Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (from OMIM 602143 and NCI) (NCI Thesaurus)
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A protein that either promotes or impedes the initiation, progress, or rate of apoptosis.
A representation of the sequence of biological or biochemical events that are involved in the regulation of or result in apoptosis. …
