Elesclomol sodium

Pronunciation

Definition 1

A drug used in the treatment of skin cancer that has spread. It is also being studied in the treatment of other types of cancer. It increases the amount of harmful oxygen molecules in cells and may kill cancer cells. It may also help other drugs kill cancer cells. It is a type of oxidative stress inducer. (NCI Dictionary)

Definition 2

The water soluble sodium salt of a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because the increase in the level of oxidative stress induced by this agent is below the threshold at which apoptosis is induced. (NCI Thesaurus)

YOU MAY ALSO LIKE

Elesclomol

A small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive…

Elephantiasis

A condition in which tissue or a limb becomes very swollen and thick, and changes color. It is caused by a…

Elementary Charge

A fundamental physical constant equal to the scalar value of positive electric charge carried by a single proton or equivalently, the negative…

Element Order

The order in which elements are organized within an arm of a clinical trial.

Element

A basic part of a whole. In chemistry, refers to a simple substance that cannot be broken down into smaller parts or…

Elekta Xio

A proprietary 3D intensity-modulated radiation therapy treatment planning platform developed by the Elekta corporation.