HMGA Family Protein

Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81) (NCI Thesaurus)

YOU MAY ALSO LIKE

HMGA Family Gene

Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors…

HMG-CoA reductase inhibitor

A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the…

HMG-CoA Lyase Deficiency

A rare genetic inherited disorder characterized by inability of the body to process the amino acid leucine. Signs and symptoms include vomiting,…

HMG-Box

The HMG-Box Domain binds to and bends the minor groove of the DNA. This domain can recognize and bind to altered DNA…

HMG Family Gene

Human HMG Family Genes encode ubiquitous non-histone HMG chromatin proteins originally named according to PAGE electrophoretic mobility, shared physical properties, and association…

HMG Domain

Each HMG subfamily is a distinct set of proteins with identifiable structural characteristics and a specific type of targets to induce characteristic…