Human Papillomavirus 16/18 L1 Virus-Like Particle/AS04 Vaccine

Definition 1

A recombinant, bivalent, human papillomavirus (HPV) vaccine, containing virus-like particles for HPV types 16 and 18 linked to the adjuvant ASO4, with potential immunoprotective and antineoplastic properties. Upon administration, HPV 16/18 L1 virus-like particle/ASO4 vaccine may generate humoral and cellular immunity against HPV types-16 and -18 antigens, thereby preventing cervical infection upon exposure to HPV types 16 and 18. In addition, this agent may stimulate an antitumoral cellular immune response against cervical cancer associated with HPV infection. (NCI Thesaurus)

Definition 2

A vaccine used to prevent cervical cancer caused by human papillomaviruses (HPV) types 16 and 18. It is also used to prevent lesions that are caused by these viruses and that can lead to cervical, vulvar, or vaginal cancer. Cervarix is used in females aged 10-25 years. It is also being studied in the treatment of other medical conditions. It is a type of bivalent vaccine. (NCI Dictionary)

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