| Health / Medical Topics |
I-Kappa-B-Beta
Widely expressed by human NFKBIB Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Beta contains 6 ANK repeats and interacts with the ligand-binding domain of Thyroid Hormone Receptor-Beta, Inhibitor Kappa B-Interacting RAS-Like Protein 1, Inhibitor Kappa B-Interacting Protein RAS2, p65 RELA, and c-REL. By complexing with and trapping NF-Kappa-B in the cytoplasm, unphosphorylated NFKBIB inhibits and likely regulates NFKB. NFKBIB phosphorylation leads to degradation. Association with Inhibitor Kappa B-Interacting RAS-Like Proteins 1 and 2 may slow degradation. (NCI Thesaurus)
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