IgG Fc Receptor IIIB

Expressed (as NA-1, NA-2, and SH allelic forms) specifically by neutrophils and stimulated eosinophils, human FCGR3B Gene encodes 233-aa 26-kDa (precursor) monomeric IgG Fc Receptor IIIB, a glycosylated (inhibits IgG3 interaction) low affinity receptor for monomeric or aggregated Fc region of IgG, attached to membrane by a GPI-anchor, and containing 2 IgC2 domains. FCGR3B also exists as a soluble receptor produced by proteolytic cleavage. Unlike FCGR3A, FCGR3B is not capable of mediating antibody-dependent cytotoxicity and phagocytosis; FCGR3B may serve as a trap for immune complexes in the peripheral circulation without activating neutrophils. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI Thesaurus)

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