Health / Medical Topics

    Liarozole

    Pronunciation

    Definition 1

    An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor. (NCI Dictionary)

    Definition 2

    An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. (NCI Thesaurus)




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