MLL-AF4 Fusion Protein Expression

Expression of a fusion protein that results from the insertion mutation ins(5;11)(q31;q13q23), which involves the human genes MLL and AFF1 and is associated with acute lymphoblastic leukemia. (NCI Thesaurus)

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MLL wt Allele

Human MLL wild-type allele is located in the vicinity of 11q23 and is approximately 89 kb in length. This allele, which encodes…

MLL Gene

This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.

MLH3 wt Allele

Human MLH3 wild-type allele is located in the vicinity of 14q24.3 and is approximately 35 kb in length. This allele, which encodes…

MLH3 Gene

This gene plays a role in DNA mismatch repair and is associated with hereditary nonpolyposis colon cancer.

MLH1 wt Allele

Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes…

MLH1 Protein

MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3. MLH1 is part…