Neurite Growth-Promoting Factor 2

NEGF2 is a member of a highly conserved, developmentally regulated human gene family. The gene product exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Expression of NEGF2 is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. The gene codes for a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. (NCI Thesaurus)

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