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Neuregulin 2
Definition 1
Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)
Definition 2
Neuregulin-2, a novel neuregulin-1-like molecule encoded by a distinct gene. Like neuregulin-1, neuregulin-2 also binds to ErbB3 and ErbB4, although it appears to signal distinctly, perhaps by activating different receptor heterodimers. Neuregulin-2 is primarily found in granule cells in the cerebellum, hippocampus, and olfactory bulb. (NCI Thesaurus)
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