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Ondansetron hydrochloride
Pronunciation
Definition 1
A drug used to prevent nausea and vomiting caused by chemotherapy and radiation therapy. It is also used to prevent nausea and vomiting after surgery. Ondansetron hydrochloride blocks the action of the chemical serotonin, which binds to certain nerves and may trigger nausea and vomiting. Blocking serotonin may help lessen nausea and vomiting. It is a type of serotonin receptor antagonist and a type of antiemetic. Also called Zofran. (NCI Dictionary)
Definition 2
The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytrptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI Thesaurus)
Definition 3
The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic. (NCI Dictionary)
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