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Palonosetron hydrochloride
Pronunciation
Definition 1
A drug used to prevent nausea and vomiting caused by chemotherapy. It is also used to prevent nausea and vomiting after surgery. Palonosetron hydrochloride blocks the action of the chemical serotonin in the brain, which may help lessen nausea and vomiting. It is a type of serotonin receptor antagonist and a type of antiemetic. Also called Aloxi. (NCI Dictionary)
Definition 2
The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB). (NCI Thesaurus)
Definition 3
A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic. (NCI Dictionary)
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