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Malignant Giant Cell Tumor of Bone
Definition 1
A high grade aggressive bone tumor, usually arising in the end of long bones. The tumor is composed of round or oval mononuclear cells, uniformly distributed osteoclast-like giant cells, and a sarcomatous spindle cell component. Clinical presentation includes pain and edema in the affected area. (NCI Thesaurus)
Definition 2
A high grade sarcoma arising in a giant cell tumor (primary) or at the site of a previously documented giant cell tumor (secondary). (NCI Thesaurus)
Definition 3
A malignant neoplasm of bone comprised of osteoclast-like giant cells and mononuclear cells. (NCI Thesaurus/CDISC)
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